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How a modification (8-aza-3-deaza-2'-deoxyguanosine) influences the quadruplex structure of Hotoda's 6-mer TGGGAG with 5'- and 3'-end modifications.

作者信息

Jaksa Suzana, Kralj Bogdan, Pannecouque Christophe, Balzarini Jan, De Clercq Erik, Kobe Joze

机构信息

National Institute of Chemistry, Ljubljana, Slovenia.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2004;23(1-2):77-88. doi: 10.1081/ncn-120027819.

DOI:10.1081/ncn-120027819
PMID:15043138
Abstract

We have synthesized a modified 6-mer using Hotoda's 6-mer TGGGAG with 5'- and 3'-end modifications as a template. We have replaced from one to all four 2'-deoxyguanosines by 8-aza-3-deaza-2'-deoxyguanosine (c3z8dG, 1) in order to investigate the anti-HIV structure activity relationship (SAR). ODN 4 (TGGG*AG) is the only one that exhibits a moderate anti-HIV-1 activity.

摘要

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引用本文的文献

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Nucleic Acids Res. 2011 Mar;39(6):2470-81. doi: 10.1093/nar/gkq1133. Epub 2010 Nov 9.