约旦地区爱泼斯坦-巴尔病毒与经典型霍奇金淋巴瘤的关联：与北美地区爱泼斯坦-巴尔病毒相关霍奇金淋巴瘤的比较研究

Association between Epstein-Barr virus and classic Hodgkin lymphoma in Jordan: a comparative study with Epstein-Barr virus-associated Hodgkin lymphoma in North America.

作者信息

Vasef Mohammad A, Ubaidat Manaf A, Khalidi Hasan S, Almasri Nidal M, Al-Abbadi Mousa, Annab Hassan Z

机构信息

Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA 52241, USA.

出版信息

South Med J. 2004 Mar;97(3):273-7. doi: 10.1097/01.SMJ.0000090035.09019.8D.

DOI:10.1097/01.SMJ.0000090035.09019.8D

PMID:15043335

Abstract

An association between Epstein-Barr virus and Hodgkin lymphoma has been shown in several parts of the world. The reported incidence of Epstein-Barr virus in Hodgkin lymphoma varies significantly from one country to another and ranges from <30% in Swedish patients to 100% in patients from Kenya. Using in situ hybridization for detection of Epstein-Barr virus-encoded RNA and immunohistochemistry for detection of Epstein-Barr virus latent membrane protein, we analyzed 28 cases of Hodgkin lymphoma from Jordan and 30 cases from the United States. Eight of 28 Jordanian cases and 9 of 30 North American cases were Epstein-Barr virus positive. Our studies show that the incidence of Epstein-Barr virus among Jordanian patients with Hodgkin lymphoma is similar to the rate in patients from the United States. This rate appears to be low to intermediate compared with rates in other parts of the world.

摘要

在世界上多个地区，已证实爱泼斯坦-巴尔病毒（EB病毒）与霍奇金淋巴瘤之间存在关联。据报道，EB病毒在霍奇金淋巴瘤中的发病率在不同国家之间差异显著，从瑞典患者中的不到30%到肯尼亚患者中的100%不等。我们采用原位杂交法检测EB病毒编码的RNA，并通过免疫组织化学法检测EB病毒潜伏膜蛋白，对来自约旦的28例霍奇金淋巴瘤病例和来自美国的30例病例进行了分析。28例约旦病例中有8例EB病毒呈阳性，30例北美病例中有9例EB病毒呈阳性。我们的研究表明，约旦霍奇金淋巴瘤患者中EB病毒的发病率与美国患者的发病率相似。与世界其他地区的发病率相比，这一发病率似乎处于低至中等水平。