Klinge C M, Bambara R A, Hilf R
Department of Biochemistry, University of Rochester Medical Center, New York 14642.
Oncol Res. 1992;4(4-5):137-44.
This paper provides an annotated summary of the current literature detailing what is known about the interaction of antiestrogen-liganded estrogen receptor (ER) vs estradiol-liganded ER with DNA in vitro and in vivo. It describes the current models of the mechanism by which antiestrogen-liganded ER blocks transcription of certain estrogen-regulated genes.
本文提供了当前文献的注释性总结，详细阐述了抗雌激素配体结合的雌激素受体（ER）与雌二醇配体结合的ER在体外和体内与DNA相互作用的已知情况。它描述了抗雌激素配体结合的ER阻断某些雌激素调节基因转录的机制的当前模型。
