McGuire W L
Cancer Res. 1982 Aug;42(8 Suppl):3420s-3423s.
The major difference observed by us between estrogen and antiestrogen pathways in breast cancer cells occurs immediately after translocation. We have called the loss of nuclear receptor following estradiol administration "processing" and have hypothesized that is is a prerequisite for estrogen stimulation in breast cancer cells and that failure of processing relates to antiestrogen effects. In the very near future, monoclonal antibody technology could be used to dissect the processing of nuclear receptor and shed now light on the mechanism of antiestrogen action.
我们观察到，乳腺癌细胞中雌激素和抗雌激素途径的主要差异在转运后立即出现。我们将雌二醇给药后核受体的丧失称为“加工”，并推测这是乳腺癌细胞中雌激素刺激的先决条件，而加工失败与抗雌激素作用有关。在不久的将来，单克隆抗体技术可用于剖析核受体的加工过程，并为抗雌激素作用机制提供新的线索。
