兔动脉粥样硬化的快速诱导
Rapid induction of atherosclerosis in rabbits.
作者信息
Saso Y, Kitamura K, Yasoshima A, Iwasaki H O, Takashima K, Doi K, Morita T
机构信息
Biological Research Laboratory, Tanabe Seiyaku Co. Ltd., Saitama, Japan.
出版信息
Histol Histopathol. 1992 Jul;7(3):315-20.
Japanese white rabbits fed a restricted amount (100 g/head/day) of an atherogenic diet (AD) containing 0.2% cholesterol and 6% peanut oil showed mild and persistent hypercholesterolemia (338 +/- 79 mg/dl). They developed atherosclerotic lesions 4 weeks after deendothelialization of aorta carried out at the 4th week of AD-feeding. This rabbit model of atherosclerosis has such advantages as being able to be produced in a short period and having similar biochemical and pathological characteristics with those in human atherosclerosis.
给日本白兔喂食限量（100克/头/天）含0.2%胆固醇和6%花生油的致动脉粥样化饮食（AD），其出现了轻度持续性高胆固醇血症（338±79毫克/分升）。在喂食AD第4周对主动脉进行去内皮处理后4周，它们出现了动脉粥样硬化病变。这种动脉粥样硬化兔模型具有能在短时间内建立以及具有与人类动脉粥样硬化相似的生化和病理特征等优点。
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