根据1995 - 2000年间3485648名首次献血者的患病率估算日本乙肝和丙肝病毒的性别及年龄特异性携带者情况。

Sex- and age-specific carriers of hepatitis B and C viruses in Japan estimated by the prevalence in the 3,485,648 first-time blood donors during 1995-2000.

作者信息

Tanaka Junko, Kumagai Junko, Katayama Keiko, Komiya Yutaka, Mizui Masaaki, Yamanaka Retsuji, Suzuki Kou, Miyakawa Yuzo, Yoshizawa Hiroshi

机构信息

Department of Epidemiology and Control of Infectious Diseases, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan.

出版信息

Intervirology. 2004;47(1):32-40. doi: 10.1159/000076640.

DOI:10.1159/000076640

PMID:15044834

Abstract

OBJECTIVE

Carriers of hepatitis B virus (HBV) and hepatitis C virus (HCV) in Japan were estimated on a national basis.

METHODS

Sera from the first-time blood donors aged 16-64 years in eight jurisdictions of the Japanese Red Cross Blood Center during 1995-2000 were tested for hepatitis B surface antigen (HBsAg) and antibody to HCV (anti-HCV). Viremia with HCV was estimated to be present in 70% of donors with anti-HCV.

RESULTS

HBsAg was detected in 22,018 of 3,485,648 (0.63%) blood donors including 12,990 of 1,780,149 (0.73%) men and 9,028 of 1,705,499 (0.53%) women, and anti-HCV in 17,010 (0.49%) including 8,504 (0.48%) men and 8,506 (0.50%) women. Multiplying the carrier rate by the population registered in the Census 2000, the total HBV carriers aged 15-65 years were estimated at 967,753 (95% confidence interval 806,760-1,128,745), of whom 571,210 (479,267-663,152) were men and 396,543 (327,494-465,593) were women. Likewise, the total HCV carriers were estimated at 884,954 (95% confidence interval 725,082-1,044,826), of whom 464,363 (377,927-550,799) were men and 420,591 (347,156-494,027) were women.

CONCLUSION

Estimated numbers of HBV and HCV carriers would help plan to prevent the development of hepatocellular carcinoma in Japan.

摘要

目的

在全国范围内估算日本乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）携带者的数量。

方法

对1995年至2000年期间日本红十字血液中心八个辖区内16至64岁首次献血者的血清进行乙型肝炎表面抗原（HBsAg）和抗丙型肝炎病毒抗体（抗-HCV）检测。估计70%抗-HCV的献血者存在丙型肝炎病毒血症。

结果

在3485648名献血者中，检测到22018人（0.63%）HBsAg呈阳性，其中男性1780149人中12990人（0.73%），女性1705499人中9028人（0.53%）；检测到17010人（0.49%）抗-HCV呈阳性，其中男性8504人（0.48%），女性8506人（0.50%）。将携带者率乘以2000年人口普查登记的人口数，估计15至65岁的HBV携带者总数为967753人（95%置信区间806760 - 1128745），其中男性571210人（479267 - 663152），女性396543人（327494 - 465593）。同样，估计HCV携带者总数为884954人（95%置信区间725082 - 1044826），其中男性464363人（377927 - 550799），女性420591人（347156 - 494027）。