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[发育年龄患者多发性硬化症干扰素治疗的当前数据]

[Current data on interferon therapy of multiple sclerosis in patients at developmental age].

作者信息

Smigielska-Kuzia Joanna, Sobaniec Wojciech, Kułak Wojciech, Boćkowski Leszek, Wołk Marzanna, Sołowiej Elzbieta, Artemowicz Barbara

机构信息

Klinika Neurologii Dzieciecej, Akademia Medyczno, ul. Waszyngtona 17, 15-354 Białystok.

出版信息

Neurol Neurochir Pol. 2004;38(1 Suppl 1):S45-51.

Abstract

Multiple sclerosis (MS) is a rare disorder of the central nervous system in children. In spite of the investigations of the last decade its etiology has not been established. The authors of the paper presented data on the specific nature of children MS using the current literature. They also demonstrated the role of interferon (INF) and clinical trials of MS treatment in children. The authors described their own experiences in the treatment of a boy with the youth MS using INF. The patient has suffered from MS since he was 15; INF therapy was introduced after two relapses of the disease. The results of the 18-month therapy with INF suggest beneficial immunomodulatory effects of interferon on MS course in children. The presented patient is continuing the therapy while his clinical status is being observed.

摘要

多发性硬化症(MS)是一种发生于儿童的罕见中枢神经系统疾病。尽管在过去十年间进行了诸多研究,但其病因仍未明确。本文作者运用当前文献资料阐述了儿童MS的特殊性质。他们还展示了干扰素(INF)的作用以及儿童MS治疗的临床试验情况。作者描述了他们使用INF治疗一名患有青少年型MS男孩的自身经验。该患者自15岁起就患有MS;在疾病两次复发后开始采用INF治疗。18个月的INF治疗结果表明,干扰素对儿童MS病程具有有益的免疫调节作用。目前该患者仍在继续接受治疗,同时其临床状况也在持续观察中。

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