Weng Min-Hsueh, Chou Cheng-Chen, Chou Hung-Chieh, Lee Tsorng-Yeh
Respiratory Care Center, Tri-Service General Hospital, Taiwan, ROC.
Hu Li Za Zhi. 2004 Feb;51(1):81-4.
The metabolites of reoxygenation accumulate as toxic free radicals during physiological reactions. During an episode of asphyxia, 100% oxygen rather than 21% oxygen is usually used for resuscitation. Excessive free radicals and cell injury may be produced during reoxygenation following the hypoxic event. Prior research has shown that resuscitation with room air (21% oxygen) may be equally effective as 100% oxygen. The side effects are also less with room air. However, evidence-based studies on this topic are limited. It is, therefore, more appropriate to follow the recommendation of Neonatal Resuscitation Program that 100% oxygen should be used during neonatal resuscitation and the oxygen concentration should be adjusted according to the different condition of individual infants.
复氧代谢产物在生理反应过程中会累积为有毒自由基。在窒息发作期间，复苏通常使用100%氧气而非21%氧气。缺氧事件后的复氧过程中可能会产生过多自由基和细胞损伤。先前的研究表明，用室内空气（21%氧气）进行复苏可能与100%氧气同样有效。使用室内空气的副作用也更小。然而，关于该主题的循证研究有限。因此，遵循新生儿复苏计划的建议更为合适，即新生儿复苏期间应使用100%氧气，并根据个别婴儿的不同情况调整氧气浓度。
