Yagyu Toshihiko, Aihara Tsukasa, Murayama Michinori, Nakamura Eisyu, Nozaki Hideto, Niida Masakuni, Yasuoka Hiroki, Nishimoto Yutaka, Watanabe Yoshinori, Syouda Shinichi, Kouno Toshihiko, Fukuhara Akinori, Nakagawa Katsuya
Dept. of Surgery, Japan Self Defense Force Hanshin Hospital.
Gan To Kagaku Ryoho. 2004 Mar;31(3):431-3.
A 54 year-old male was admitted for highly advanced ascending colon cancer with multiple bone and liver metastases and pleuritis carcinomatosa. He was treated with pharmacokinetic modulating chemotherapy (PMC) and low-dose CPT-11. UFT (400 mg) was orally administered daily and a 2-hour infusion of l-leucovorin (250 mg/m2/day) with a continuous infusion of 5-FU (600 mg/m2/24 h) was given once a week on an outpatient basis. CPT-11 (80 mg/body/2 h) was administered every 2 weeks. Partial response was obtained in the liver for 6 months and in the primary lesion for 9 months. Significant decrease of pain from the multiple bone metastases was observed for 4 months without severe side effects, which led to an improvement in performance status and quality of life for the patient. He survived more than 11 months after initial treatment. The duration of his stay at home was 288 days, accounting for 83% of the treatment period. This case suggests the efficacy of home anticancer therapy with PMC and low-dose CPT-11 for highly advanced colon cancer in terms of QOL.
一名54岁男性因晚期升结肠癌伴多发骨转移、肝转移及癌性胸膜炎入院。他接受了药代动力学调节化疗（PMC）和低剂量伊立替康治疗。每日口服优福定（400mg），门诊每周一次静脉滴注左亚叶酸（250mg/m²/天）2小时，同时持续静脉滴注5-氟尿嘧啶（600mg/m²/24小时）。每2周静脉滴注伊立替康（80mg/体/2小时）。肝脏病灶部分缓解持续6个月，原发灶部分缓解持续9个月。多发骨转移所致疼痛明显减轻，持续4个月，且无严重副作用，患者的身体状况和生活质量得到改善。初始治疗后患者存活超过11个月。他在家中停留的时间为288天，占治疗期的83%。该病例提示，就生活质量而言，PMC联合低剂量伊立替康居家抗癌治疗对晚期结肠癌有效。
