Zhen W, Yaotian H, Songjian L, Ge L, Qingliang W
Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xian City, Shannxi, China.
J Bone Joint Surg Br. 2004 Mar;86(2):212-6. doi: 10.1302/0301-620x.86b2.14362.
Giant-cell tumour of bone (GCT) is a locally benign aggressive tumour. The use of adjuvant agents, such as phenol or liquid nitrogen has been recommended to destroy the remaining tumour cells after curettage, and filling of the defect with methylmethacrylate cement has been advocated. Between 1957 and 1992 we treated 92 patients with a GCT with 50% aqueous zinc chloride solution and bone grafting. Their mean age at the time of surgery was 31 years (15 to 59) and the mean follow-up was 11 years (5 to 31). Twelve (13%) had a local recurrence and one had a wound infection. Two developed degenerative changes around the knee. Eighty-six (93%) achieved good or excellent function. Three had moderate function, and three needed amputation. Our findings indicate that treatment with an aqueous solution of zinc chloride and reconstructive bone grafting after curettage gives good results.
骨巨细胞瘤（GCT）是一种局部具有侵袭性的良性肿瘤。有人建议使用辅助剂，如苯酚或液氮，以在刮除术后破坏残留的肿瘤细胞，并主张用甲基丙烯酸甲酯骨水泥填充骨缺损。1957年至1992年间，我们用50%的氯化锌水溶液和骨移植治疗了92例骨巨细胞瘤患者。他们手术时的平均年龄为31岁（15至59岁），平均随访时间为11年（5至31年）。12例（13%）出现局部复发，1例发生伤口感染。2例在膝关节周围出现退行性改变。86例（93%）功能良好或极佳。3例功能中等，3例需要截肢。我们的研究结果表明，刮除术后用氯化锌水溶液治疗并进行重建性骨移植可取得良好效果。
