Dommergues M, Aubény E, Dumez Y, Durandy A, Coulombel L
Maternité Port Royal, Paris, France.
Bone Marrow Transplant. 1992;9 Suppl 1:23-7.
In a first attempt to investigate the regulation of the early steps of human embryonic hematopoiesis, we measured the number of erythroid and granulopoietic progenitors in 38 human yolk sacs and 15 embryonic livers between 27 and 62 days of development. Both erythroid and granulopoietic progenitors were identified in the yolk sac as soon as 27 days, while in the embryonic liver significant numbers were not observed before 40 days. In the yolk sac, the number of granulopoietic and/or macrophagic progenitors was significantly negatively correlated with gestational age. Such a correlation was not observed for CFU-E and BFU-E, even though in the youngest (less than 30 days) and the oldest embryos studied (greater than 40 days), the number of BFU-E was clearly lower.
为了首次探究人类胚胎造血早期阶段的调控机制，我们测量了38个发育27至62天的人类卵黄囊和15个胚胎肝脏中红系和粒系祖细胞的数量。早在27天时，卵黄囊中就已鉴定出红系和粒系祖细胞，而在胚胎肝脏中，40天之前未观察到大量的此类细胞。在卵黄囊中，粒系和/或巨噬系祖细胞的数量与胎龄呈显著负相关。对于CFU-E和BFU-E，未观察到这种相关性，尽管在研究的最年幼胚胎（小于30天）和最年长胚胎（大于40天）中，BFU-E的数量明显较低。
