Kanamaru A, Nakayama H, Okuda K, Matsuda K, Kitamura Y, Nagai K
Int J Cell Cloning. 1987 Mar;5(2):134-41. doi: 10.1002/stem.5530050205.
Remarkable differences were found between late erythroid progenitors (CFU-e) in cultures of murine yolk sac cells and those of fetal liver cells with respect to frequency, erythropoietin responsiveness and colony size. Cultures of yolk sac on day 11 of gestation showed a CFU-e population of lower frequency, less sensitivity to erythropoietin and smaller colony size than those from cultures of day 14 fetal liver cells. As the proportion of CFU-e to BFU-e was much lower in yolk sac than that in fetal liver, 48-96 h liquid culture experiments were done with these cells to examine the capacity of their precursors to generate a certain amount of CFU-e subpopulations. The cultures of yolk sac cells produced large numbers of CFU-e which formed some large-sized colonies but those of fetal liver cells generated only a small amount of CFU-e.
在小鼠卵黄囊细胞和胎儿肝细胞培养物中的晚期红系祖细胞（CFU-e）之间，在频率、促红细胞生成素反应性和集落大小方面发现了显著差异。妊娠第11天的卵黄囊培养物显示，CFU-e群体的频率低于第14天胎儿肝细胞培养物中的CFU-e群体，对促红细胞生成素的敏感性较低，集落大小也较小。由于卵黄囊中CFU-e与BFU-e的比例远低于胎儿肝脏中的比例，因此对这些细胞进行了48 - 96小时的液体培养实验，以检查其前体细胞产生一定数量CFU-e亚群的能力。卵黄囊细胞培养物产生了大量形成一些大尺寸集落的CFU-e，而胎儿肝细胞培养物仅产生少量CFU-e。
