Bilici Ahmet, Doventas Alper, Karadag Berrin, Hekim Nezih, Tezcan Vecdet
Department of Internal Medicine, Cerrahpasa School of Medicine, Istanbul, Turkey.
Gynecol Oncol. 2004 Apr;93(1):269-71. doi: 10.1016/j.ygyno.2004.01.013.
Humoral hypercalcemia is known to be an important cause of hypercalcemia associated with malignancy. Humoral hypercalcemia due to benign conditions has been rarely reported.
We report on a 45-year-old woman with humoral hypercalcemia secondary to uterine leiomyoma. Following the surgical removal of leiomyoma by hysterectomy, serum calcium, suppressed parathyroid hormone (PTH) and elevated parathyroid hormone-related protein (PTH-rP) levels were normalized.
To our knowledge, this is the second reported case of humoral hypercalcemia associated with uterine leiomyoma. We suggest that for women with hypercalcemia who had suppressed PTH and elevated PTH-rP levels, uterine leiomyoma should be included in the differential diagnosis.
体液性高钙血症是已知的与恶性肿瘤相关的高钙血症的重要原因。由良性疾病引起的体液性高钙血症鲜有报道。
我们报告一名45岁女性，因子宫平滑肌瘤继发体液性高钙血症。经子宫切除术手术切除平滑肌瘤后，血清钙、受抑制的甲状旁腺激素（PTH）和升高的甲状旁腺激素相关蛋白（PTH-rP）水平恢复正常。
据我们所知，这是第二例报道的与子宫平滑肌瘤相关的体液性高钙血症病例。我们建议，对于PTH受抑制且PTH-rP水平升高的高钙血症女性，鉴别诊断应包括子宫平滑肌瘤。
