妊娠期间的高钙血症——一个多方面的挑战：病例报告与文献综述
Hypercalcemia in pregnancy - a multifaceted challenge: case reports and literature review.
作者信息
Rey Evelyne, Jacob Claude-Emilie, Koolian Maral, Morin Francine
机构信息
CHU Sainte-Justine Research CenterMontrealQuebecCanada; Division of Obstetric MedicineDepartment of Obstetrics and GynaecologyCHU Sainte-JustineMontrealQuebecCanada; Department of MedicineUniversity of MontrealMontrealQuebecCanada.
Division of Maternal-Fetal Medicine Department of Obstetrics and Gynaecology Centre Hospitalier de l'Université de Montréal Montreal Quebec Canada.
出版信息
Clin Case Rep. 2016 Sep 17;4(10):1001-1008. doi: 10.1002/ccr3.646. eCollection 2016 Oct.
Abstract
Hypercalcemia in pregnancy is an uncommon event that can cause major maternal morbidity and/or fetal or neonatal morbidity and mortality. Management is a challenge for the clinicians, especially as regards to investigations in pregnancy, surgery, and the use of cinacalcet and bisphosphonates. We present three case reports and discuss management.
摘要
妊娠期高钙血症是一种罕见的情况，可导致严重的母体发病和/或胎儿或新生儿发病及死亡。对于临床医生来说，管理是一项挑战，尤其是在妊娠期检查、手术以及西那卡塞和双膦酸盐的使用方面。我们呈现三例病例报告并讨论管理方法。
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本文引用的文献
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J Clin Endocrinol Metab. 2015 May;100(5):2115-22. doi: 10.1210/jc.2015-1110. Epub 2015 Mar 9.
2
The use of cinacalcet in pregnancy to treat a complex case of parathyroid carcinoma.西那卡塞在孕期用于治疗一例复杂甲状旁腺癌病例。
Endocrinol Diabetes Metab Case Rep. 2014;2014:140056. doi: 10.1530/EDM-14-0056. Epub 2014 Sep 1.
3
"Parathyroidectomy in pregnancy"-a single centre experience with review of evidence and proposal for treatment algorithim.“妊娠期甲状旁腺切除术”——单中心经验、证据回顾及治疗算法建议
Gland Surg. 2014 Aug;3(3):158-64. doi: 10.3978/j.issn.2227-684X.2014.02.04.
4
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Eur J Pharmacol. 2013 Jul 15;712(1-3):8-15. doi: 10.1016/j.ejphar.2013.04.013. Epub 2013 Apr 23.
6
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7
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Hormones (Athens). 2011 Oct-Dec;10(4):280-91. doi: 10.14310/horm.2002.1319.
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