Bastard J-P
Service de biochimie et hormonologie, Hôpital Tenon, 4, rue de la Chine, 75970 Paris.
Ann Biol Clin (Paris). 2004 Jan-Feb;62(1):25-31.
Obesity is a risk factor for type 2 diabetes and cardiovascular diseases. The hypothesis that cytokines could play a role in the pathophysiology of obesity and insulin resistance is suggested in the last few years. We showed a positive correlation between circulating interleukin (IL-6) levels and obesity and insulin resistance suggesting that IL-6 could be involved in insulin resistance in humans. We showed a decrease of both circulating and adipose tissue IL-6 levels in non-diabetic obese subjects after a very low calorie diet program inducing weight loss. This suggests that adipose tissue could be involved in the regulation of circulating IL-6 levels in these subjects. Adipose tissue is also involved in lipodystrophies particularly in HIV patients on antiviral therapy. We showed an alteration of the SREBP-1 transcription step in subcutaneous abdominal adipose tissue from HIV patients. We found an inverse correlation between circulating adiponectin levels and both insulin resistance and cardiovascular risk factors such as CRP levels and apolipoprotein B/A1 ratio. These findings suggest that adipose tissue is involved in insulin resistance in humans particularly via adipocytokine secretion.
肥胖是2型糖尿病和心血管疾病的一个危险因素。在过去几年中，有人提出细胞因子可能在肥胖和胰岛素抵抗的病理生理学中发挥作用这一假说。我们发现循环白细胞介素（IL-6）水平与肥胖及胰岛素抵抗之间存在正相关，这表明IL-6可能参与人体的胰岛素抵抗。在一个导致体重减轻的极低热量饮食方案实施后，我们发现非糖尿病肥胖受试者的循环及脂肪组织IL-6水平均有所下降。这表明脂肪组织可能参与了这些受试者循环IL-6水平的调节。脂肪组织也与脂肪营养不良有关，尤其是在接受抗病毒治疗的HIV患者中。我们发现HIV患者腹部皮下脂肪组织中SREBP-1转录步骤存在改变。我们发现循环脂联素水平与胰岛素抵抗以及心血管危险因素如CRP水平和载脂蛋白B/A1比值之间呈负相关。这些发现表明脂肪组织参与人体的胰岛素抵抗，特别是通过脂肪细胞因子的分泌。
