亚抑菌浓度的一线抗生素会诱导肺炎衣原体持续存在。
First-choice antibiotics at subinhibitory concentrations induce persistence of Chlamydia pneumoniae.
作者信息
Gieffers Jens, Rupp Jan, Gebert Andreas, Solbach Werner, Klinger Matthias
机构信息
Institute of Medical Microbiology and Hygiene, University of Lübeck, 23538 Luebeck, Germany.
出版信息
Antimicrob Agents Chemother. 2004 Apr;48(4):1402-5. doi: 10.1128/AAC.48.4.1402-1405.2004.
Abstract
Persistent growth forms of Chlamydia pneumoniae have been associated with chronic infections in vivo. We investigated the effects of first-line therapeutics on the induction of persistence by monitoring recoverable organisms, gene expression of membrane proteins, and morphology. We found that all of the antibiotics tested have distinct and subinhibitory concentrations at which they induce persistence.
摘要
肺炎衣原体的持续生长形式与体内慢性感染有关。我们通过监测可恢复的生物体、膜蛋白的基因表达和形态，研究了一线治疗药物对持续性诱导的影响。我们发现，所有测试的抗生素都有不同的亚抑制浓度，在这些浓度下它们会诱导持续性。
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