阿莫西林-克拉维酸治疗后急性中耳炎患儿鼻咽部菌群中肺炎链球菌的清除情况。
Eradication of Streptococcus pneumoniae in the nasopharyngeal flora of children with acute otitis media after amoxicillin-clavulanate therapy.
作者信息
Brook Itzhak, Gober Alan E
机构信息
Department of Pediatrics, Georgetown University School of Medicine, Washington, D.C. 20016, USA.
出版信息
Antimicrob Agents Chemother. 2004 Apr;48(4):1419-21. doi: 10.1128/AAC.48.4.1419-1421.2004.
Abstract
Nasopharyngeal cultures were obtained from 60 children with acute otitis media before and after treatment with either 45 or 90 mg of amoxicillin (given as amoxicillin-clavulanate) per kg of body weight per day for 10 days. The number of Streptococcus pneumoniae isolates in the 45-mg/kg group was reduced from 12 to 6 and was reduced from 14 to 1 (P = 0.0261) in the 90-mg/kg group.
摘要
对60名患有急性中耳炎的儿童在接受治疗前后进行了鼻咽培养，治疗方案为每天每千克体重给予45毫克或90毫克阿莫西林（以阿莫西林 - 克拉维酸盐形式给药），持续10天。45毫克/千克组的肺炎链球菌分离株数量从12株减少到6株，90毫克/千克组从14株减少到1株（P = 0.0261）。
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