Hyde J F
Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington 40536-0084.
Brain Res. 1992 Feb 28;573(2):204-8. doi: 10.1016/0006-8993(92)90764-z.
The effects of acute and chronic exposure to phencyclidine (PCP) on the regulation of prolactin (PRL) secretion were examined. Female Sprague-Dawley rats were injected with PCP (10 mg/kg) or saline for 14 days, or just prior to the administration of the serotonin precursor, 5-hydroxytryptophan (5-HTP). A single injection of PCP had no effect on the 5-HTP-induced rise of plasma PRL levels. In contrast, chronic administration of PCP facilitated the release of PRL induced by 5-HTP. Peak plasma PRL levels were more than 3-fold higher after chronic PCP. The acute effect of PCP on suckling-induced PRL release was also examined. PCP delayed the rise of plasma PRL levels by suckling. The magnitude and profile of PRL, however, were similar to saline controls. The pups of PCP-treated dams failed to obtain milk during the suckling episode. Exogenous oxytocin restored the milk ejection reflex in PCP-treated dams. PCP had no effect on basal PRL release from anterior pituitary cells in vitro, and failed to alter the effects of TRH or dopamine.
(1) chronic, but not acute, administration of PCP facilitates the 5-HTP-induced release of PRL, (2) acute exposure to PCP delays the suckling-induced rise in PRL and appears to inhibit oxytocin release. These data demonstrate that both acute and chronic PCP may alter the regulation of PRL release, likely through an indirect central mechanism.
研究了急性和慢性暴露于苯环利定（PCP）对催乳素（PRL）分泌调节的影响。将雌性斯普拉格-道利大鼠注射PCP（10毫克/千克）或生理盐水，持续14天，或者在给予血清素前体5-羟色氨酸（5-HTP）之前注射。单次注射PCP对5-HTP诱导的血浆PRL水平升高没有影响。相比之下，慢性给予PCP促进了5-HTP诱导的PRL释放。慢性给予PCP后，血浆PRL峰值水平高出3倍多。还研究了PCP对哺乳诱导的PRL释放的急性影响。PCP延迟了哺乳引起的血浆PRL水平升高。然而，PRL的幅度和变化曲线与生理盐水对照组相似。PCP处理的母鼠的幼崽在哺乳期间未能获得乳汁。外源性催产素恢复了PCP处理的母鼠的排乳反射。PCP对体外垂体前叶细胞的基础PRL释放没有影响，也未能改变促甲状腺激素释放激素（TRH）或多巴胺的作用。
（1）慢性而非急性给予PCP促进5-HTP诱导的PRL释放，（2）急性暴露于PCP延迟哺乳诱导的PRL升高，并且似乎抑制催产素释放。这些数据表明，急性和慢性PCP都可能通过间接的中枢机制改变PRL释放的调节。
