Jiao S, Schultz E, Wolff J A
Department of Pediatrics and Medical Genetics, Waisman Center, University of Wisconsin, Madison 53706.
Brain Res. 1992 Mar 13;575(1):143-7. doi: 10.1016/0006-8993(92)90434-b.
After the transplantation of rat primary muscle cells into the caudate or cortex of recipient rats, the muscle cells were able to persist for at least 6 months. Muscle cells transfected with expression plasmids prior to transplantation were able to express reporter genes in the brains for at least 2 months. These results suggest that muscle cells might be a useful 'platform' for transgene expression in the brain.
将大鼠原代肌肉细胞移植到受体大鼠的尾状核或皮层后，肌肉细胞能够存活至少6个月。移植前用表达质粒转染的肌肉细胞能够在大脑中表达报告基因至少2个月。这些结果表明，肌肉细胞可能是大脑中转基因表达的一个有用“平台”。
