Jiao S, Wolff J A
Department of Pediatrics and Medical Genetics, Waisman Center, University of Wisconsin, Madison 53706.
Neurosci Lett. 1992 Mar 30;137(2):207-10. doi: 10.1016/0304-3940(92)90405-v.
The ability of muscle to persist in the brain was explored. Pieces of rat quadriceps muscles were removed, minced and transplanted back into the same animal's cortex. Brains implanted with minced muscle consistently contained substantial grafts for at least 6 months. Histological, immunohistochemical, and electron microscopic examination indicated that the muscle grafts after 6 months contained healthy and well-differentiated myofibers. The long-term survival of muscle cells suggested that this technique will be useful for studies of brain and muscle and for the development of new therapeutic modalities.
研究了肌肉在大脑中持续存在的能力。切除大鼠股四头肌小块，切碎后移植回同一动物的大脑皮层。植入切碎肌肉的大脑在至少6个月内始终含有大量移植物。组织学、免疫组织化学和电子显微镜检查表明，6个月后的肌肉移植物含有健康且分化良好的肌纤维。肌肉细胞的长期存活表明，该技术将有助于脑和肌肉的研究以及新治疗方法的开发。
