Robinson M R, Lee S S, Rubin B I, Wayne A S, Pavletic S Z, Bishop M R, Childs R, Barrett A J, Csaky K G
National Eye Institute/NIH, 10/10S229, 110 Center Drive, MSC 1863, Bethesda, MD 20892-1863, USA.
Bone Marrow Transplant. 2004 May;33(10):1031-5. doi: 10.1038/sj.bmt.1704453.
A retrospective chart review was performed on seven patients treated with topical ocular corticosteroid therapy for progressive cicatricial conjunctivitis associated with chronic graft-versus-host disease (GVHD) following hematopoietic stem cell transplantation. A clinical grading criteria for conjunctival GVHD based on the degree of cicatrization was developed and patients graded prior to therapy. During the treatment course, the dose and frequency of topical corticosteroids and clinical outcomes were recorded. A complete response was defined as a complete resolution of the conjunctival hyperemia with either total resolution of the conjunctival fibrovascularization or presence of inactive conjunctival scarring. Prednisolone acetate 1% eye drops were used in a total of eight courses of therapy in seven patients. A complete response was documented in all seven patients with a total treatment duration of 7 weeks (median, range: 3-16 weeks). Additional studies are required to determine the long-term safety and efficacy of topical corticosteroids for cicatricial conjunctivitis associated with ocular GVHD in the context of a randomized, prospective clinical trial.
对7例造血干细胞移植后因慢性移植物抗宿主病（GVHD）导致进行性瘢痕性结膜炎而接受局部眼部皮质类固醇治疗的患者进行了回顾性病历审查。制定了基于瘢痕化程度的结膜GVHD临床分级标准，并在治疗前对患者进行分级。在治疗过程中，记录局部皮质类固醇的剂量和频率以及临床结果。完全缓解定义为结膜充血完全消退，结膜纤维血管化完全消退或存在不活动的结膜瘢痕。7例患者共使用了8个疗程的1%醋酸泼尼松龙滴眼液。所有7例患者均记录为完全缓解，总治疗持续时间为7周（中位数，范围：3 - 16周）。需要进行额外的研究，以在随机、前瞻性临床试验的背景下确定局部皮质类固醇治疗与眼部GVHD相关的瘢痕性结膜炎的长期安全性和有效性。
