Wu Y Q, Wang Y, Zhang W G, Zhang Z Y
School of Stomatology,Shanghai Second Medical University. Shanghai 200011, China.
Shanghai Kou Qiang Yi Xue. 1999 Sep;8(3):159-62.
The present study was to investigate the expression of CD44s and CD44v6 in human salivary adenoid cystic carcinoma (ACC) and to discuss the relationship between the expression of the proteins and the biological characteristic of ACC.METHODS:Formalin fixed,paraffin embedded sections in 10 cases of normal salivary glands and 50 cases of human salivary ACC were examined using immunostaining for CD44s and CD44v6.RESULTS:(1)Positive signals of CD44s and CD44v6 were detected in all the specimens of normal salivary glands.Positive signals of CD44s and CD44v6 were detected in 29(58%) and 35(70%) of the 50 cases of ACC.(2)The expression of CD44s and CD44v6 in the solid pattern of ACC was significantly less than that in the cribriform and tubular pattern of ACC(P<0.05).(3)Positive CD44s staining was detected in 3(13.6%) of the 22 ACC primary sites which had a local recurrence after operation.CONCLUSION:(1)Adhesion molecules including CD44s and CD44v6 may contribute to maintain the normal structures in salivary gland tissues.(2)T he down-regulation or loss of CD44s expression was contributed to the recurrence of human salivary ACC and CD44s could be regarded as one of the factors to evaluate the prognosis of ACC patients.
本研究旨在探讨CD44s和CD44v6在人涎腺腺样囊性癌（ACC）中的表达情况，并探讨其与ACC生物学特性之间的关系。方法：采用免疫组化法检测10例正常涎腺组织及50例人涎腺ACC组织的福尔马林固定、石蜡包埋切片中CD44s和CD44v6的表达。结果：（1）所有正常涎腺组织标本均检测到CD44s和CD44v6阳性信号。50例ACC中，29例（58%）检测到CD44s阳性信号，35例（70%）检测到CD44v6阳性信号。（2）ACC实性型中CD44s和CD44v6的表达明显低于筛状型和管状型（P<0.05）。（3）术后局部复发的22例ACC原发灶中，3例（13.6%）检测到CD44s阳性染色。结论：（1）包括CD44s和CD44v6在内的黏附分子可能有助于维持涎腺组织的正常结构。（2）CD44s表达下调或缺失与人涎腺ACC的复发有关，CD44s可作为评估ACC患者预后的因素之一。
