Szekely A, Ronai Z, Nemoda Z, Kolmann G, Gervai J, Sasvari-Szekely M
Department of Experimental Psychology, Institute of Psychology, Eotvos Lorand University, Izabella u. 46, Budapest 1064, Hungary.
Am J Med Genet B Neuropsychiatr Genet. 2004 Apr 1;126B(1):106-10. doi: 10.1002/ajmg.b.20134.
The associations of human personality traits as measured by the Temperament and Character Inventory (TCI) with two genetic polymorphisms, the dopamine D4 receptor (DRD4) gene exon III repeat polymorphism (VNTR) and the serotonin transporter-linked functional polymorphism (5-HTTLPR) are presented in a population of 157 ethnically homogeneous Caucasians. No association was found between Novelty Seeking and the DRD4 VNTR, but male individuals with a 7-repeat allele exhibited significantly lower Persistence scores. The 5-HTTLPR polymorphism itself had no significant effect on any of the temperament dimensions, but a significant DRD4 VNTR x 5-HTTLPR interaction was observed for Harm Avoidance, the subgroup with a s/s 5-HTTLPR, 7-repeat DRD4 genotype showed a higher mean Harm Avoidance score than the other groups. These results are discussed in relation to the recent findings on infant temperament. Association between the DRD4 7-repeat allele and Persistence can be theoretically linked to the 7-repeat allele as a risk factor for attention deficit hyperactivity disorder.
在一个由157名种族同质的高加索人组成的群体中，呈现了通过气质和性格量表（TCI）测量的人类人格特质与两种基因多态性之间的关联，这两种基因多态性分别是多巴胺D4受体（DRD4）基因外显子III重复多态性（VNTR）和血清素转运体相关功能多态性（5-HTTLPR）。在新奇寻求与DRD4 VNTR之间未发现关联，但具有7重复等位基因的男性个体表现出显著更低的坚持性得分。5-HTTLPR多态性本身对任何气质维度均无显著影响，但在避免伤害方面观察到显著的DRD4 VNTR×5-HTTLPR相互作用，具有s/s 5-HTTLPR、7重复DRD4基因型的亚组显示出比其他组更高的平均避免伤害得分。结合近期关于婴儿气质的研究结果对这些结果进行了讨论。DRD4 7重复等位基因与坚持性之间的关联理论上可与作为注意力缺陷多动障碍风险因素的7重复等位基因联系起来。
