Joyce Peter R, Rogers Geraldine R, Miller Allison L, Mulder Roger T, Luty Suzanne E, Kennedy Martin A
Department of Psychological Medicine, Christchurch School of Medicine and Health Sciences, P.O. Box 4345, Christchurch, New Zealand.
Psychiatry Res. 2003 Jul 15;119(1-2):1-10. doi: 10.1016/s0165-1781(03)00124-0.
We investigated whether polymorphisms of the dopamine D4 receptor (DRD4) and polymorphisms of the dopamine D3 receptor (DRD3) were associated with personality disorder symptomatology rather than with personality traits such as novelty seeking. DNA was obtained from 145 depressed patients in a clinical trial. These patients were assessed for the presence of personality disorder symptoms and disorders. The 2-repeat allele of the DRD4 exon III polymorphism was associated with increased rates of avoidant and obsessive personality disorder symptomatology. The T,T genotype of the DRD4 -521 C>T polymorphism was also associated with increased rates of avoidant and obsessive personality disorder symptomatology. The Gly9,Gly9 genotype of the DRD3 Ser9Gly polymorphism was associated with increased rates of obsessive personality disorder symptomatology. None of these three polymorphisms were associated with novelty seeking or other temperament traits on the Temperament and Character Inventory. Our results suggest that genetic polymorphisms of DRD4 and DRD3 may well be associated with personality traits, and that conflicting findings to date may arise from the problem of phenotype definition.
我们研究了多巴胺D4受体（DRD4）的多态性和多巴胺D3受体（DRD3）的多态性是否与人格障碍症状相关，而非与诸如寻求新奇等人格特质相关。在一项临床试验中，从145名抑郁症患者身上获取了DNA。对这些患者的人格障碍症状和疾病的存在情况进行了评估。DRD4外显子III多态性的2重复等位基因与回避型和强迫型人格障碍症状发生率增加相关。DRD4 -521 C>T多态性的T,T基因型也与回避型和强迫型人格障碍症状发生率增加相关。DRD3 Ser9Gly多态性的Gly9,Gly9基因型与强迫型人格障碍症状发生率增加相关。这三种多态性均与气质与性格量表上的寻求新奇或其他气质特质无关。我们的结果表明，DRD4和DRD3的基因多态性很可能与人格特质相关，并且迄今为止相互矛盾的研究结果可能源于表型定义问题。
