Mornex R, Peyrin L, Badet C
Service d'endocrinologie et des maladies métaboliques, Pavillon X, hôpital Edouard Herriot, Lyon.
Bull Acad Natl Med. 1992 Apr;176(4):545-53; discussion 553-5.
The study of a personal series of 85 cases observed by the same endocrinologist over a period of 40 years shows the modifications of clinical presentation and biological methods of diagnosis and treatment. There is a striking increase in the percentage of patients without any cardiac or vascular manifestations. The methoxyamines assay has the best sensitivity and specificity even in asymptomatic tumors. The recent development of this assay in the blood is very efficient. The tumor may be found with an abdominal CT scan. The use of NMR is not fruitful. The 131I MIBG scintigraphy is necessary if the CT scan is not informative and in malignant forms. The malignancy is more frequent (16.5%) than classical according to the long duration of the disease. The quite good prognosis is improved by the administration of 131I MIBG. The surgery was safer and without mortality over the last 15 years.
对同一位内分泌学家在40年期间观察的85例个人病例系列研究显示了临床表现以及诊断和治疗生物学方法的变化。无任何心脏或血管表现的患者百分比显著增加。即使在无症状肿瘤中,甲氧胺测定也具有最佳的敏感性和特异性。该测定在血液中的最新进展非常有效。肿瘤可通过腹部CT扫描发现。核磁共振成像(NMR)的使用没有成效。如果CT扫描信息不足以及在恶性形式中,131I间碘苄胍(MIBG)闪烁扫描是必要的。根据疾病的长期病程,恶性肿瘤比经典情况更常见(16.5%)。131I MIBG的给药改善了相当不错的预后。在过去15年中,手术更安全且无死亡率。