Pelizon A C, Kaneno R, Soares A M, Meira D A, Sartori A
Departamento de Microbiologia e Imunologia, Instituto de Biociências da Unesp, Faculdade de Medicina, Campus de Botucatu, 18618-000 Botucatu, SP, Brasil.
Mem Inst Oswaldo Cruz. 2003 Dec;98(8):1083-7. doi: 10.1590/s0074-02762003000800019.
beta-glucan, one of the major cell wall components of Saccharomyces cerevisiae, has been found to enhance immune functions. This study investigated in vivo and in vitro effects of beta-glucan on lymphoproliferation and interferon-gamma (IFN-gamma) production by splenic cells from C57BL/6 female mice. All experiments were performed with particulate beta-glucan derived from S. cerevisiae. Data demonstrated that both, i.p. administration of particulate beta-glucan (20 or 100 micrograms/animal) and in vitro stimulation of splenic cells (20 or 100 micrograms/ml of culture) decreased lymphoproliferation and IFN-gamma production induced by concanavalin A. These results suggest that beta-glucan can trigger a down-modulatory effect regulating a deleterious immune system hyperactivity in the presence of a strong stimulus.
β-葡聚糖是酿酒酵母主要的细胞壁成分之一，已被发现可增强免疫功能。本研究调查了β-葡聚糖对C57BL/6雌性小鼠脾细胞淋巴细胞增殖和γ-干扰素（IFN-γ）产生的体内和体外效应。所有实验均使用源自酿酒酵母的颗粒状β-葡聚糖进行。数据表明，腹腔注射颗粒状β-葡聚糖（20或100微克/动物）以及体外刺激脾细胞（20或100微克/毫升培养物）均降低了伴刀豆球蛋白A诱导的淋巴细胞增殖和IFN-γ产生。这些结果表明，在存在强烈刺激的情况下，β-葡聚糖可引发下调效应，调节有害的免疫系统过度活跃。
