Tait K F, Marshall T, Berman J, Carr-Smith J, Rowe B, Todd J A, Bain S C, Barnett A H, Gough S C L
Department of Medicine, University of Birmingham, Birmingham, UK.
Diabet Med. 2004 Apr;21(4):358-62. doi: 10.1111/j.1464-5491.2004.01162.x.
Autoimmune disorders co-exist in the same individuals and in families, implying a shared aetiology. The aim of this study was to compare the prevalence of the common autoimmune diseases in the parents of siblings from the Type 1 diabetes Warren repository with the general population.
Between 1989 and 1996, 505 British families with at least two siblings affected by Type 1 diabetes were recruited. Clinical information was collected regarding the presence of autoimmune disease in the parents and the prevalence of disease in the parents was compared with that expected in the general population.
The prevalence of autoimmune disease in the parents was significantly higher in the repository compared with that expected in the general population [P-value = 1.98 x 10(-5) (female), P-value = 1.1 x 10(-8) (male)]. Type 1 diabetes was recorded in 63/1010 (6.2%) parents with a marked paternal preponderance (9.5 vs. 3%P = 0.002). Other autoimmune diseases affected 27% of parents with diabetes and 13.2% of parents without diabetes (P < 0.01).
These data confirm the importance of family history as a significant risk factor for the development of Type 1 diabetes and support the hypothesis that the common autoimmune diseases share at least some aetiological mechanisms.
自身免疫性疾病在同一个体及家族中共同存在，这意味着存在共同的病因。本研究的目的是比较1型糖尿病沃伦资料库中同胞兄弟姐妹的父母与普通人群中常见自身免疫性疾病的患病率。
在1989年至1996年期间，招募了505个至少有两个患1型糖尿病同胞的英国家庭。收集了有关父母自身免疫性疾病存在情况的临床信息，并将父母中疾病的患病率与普通人群中预期的患病率进行比较。
与普通人群中预期的患病率相比，资料库中父母自身免疫性疾病的患病率显著更高[P值 = 1.98 x 10(-5)（女性），P值 = 1.1 x 10(-8)（男性）]。1010名父母中有63名（6.2%）被记录患有1型糖尿病，父亲患病率明显更高（9.5%对3%，P = 0.002）。其他自身免疫性疾病在患糖尿病的父母中占27%，在未患糖尿病的父母中占13.2%（P < 0.01）。
这些数据证实了家族史作为1型糖尿病发病的重要危险因素的重要性，并支持了常见自身免疫性疾病至少共享一些病因机制的假设。
