FAS 基因-670 A/G 和-1377 G/A 多态性与自身免疫性疾病风险的关联：一项荟萃分析。
Association between FAS gene -670 A/G and -1377 G/A polymorphisms and the risk of autoimmune diseases: a meta-analysis.
机构信息
NHC/Ministry of Education/Liaoning Province Key Laboratory of Immunodermatology (China Medical University), Department of Dermatology, The First Hospital of China Medical University, No.155 Nanjing Bei Street, Heping District, Shenyang, Liaoning Province, P.R. China 110001.
出版信息
Biosci Rep. 2020 Jan 31;40(1). doi: 10.1042/BSR20191197.
OBJECTIVES
FAS plays a critical role in the extrinsic apoptosis pathway in autoimmune diseases. Previous studies investigating the association between FAS gene -670 A/G and -1377 G/A polymorphisms and the risk of autoimmune diseases reported controversial results. We performed the meta-analysis to evaluate the possible association.
METHODS
Relevant studies were identified by searching the PubMed, Embase, CNKI, and Wanfang databases up to December 2018. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated to determine the association.
RESULTS
A total of 43 articles including 67 studies (52 studies for FAS -670 A/G and 15 studies for -1377 G/A) were included in the meta-analysis. Our meta-analysis showed that the FAS -670 A/G polymorphism was associated with the risk of autoimmune diseases (GG vs. GA: OR = 1.079, 95% CI = 1.004-1.160, P=0.038), especially in Caucasians (GG vs. GA: OR = 1.12, 95% CI = 1.03-1.23, P=0.012), Asians (G vs. A: OR = 0.89, 95% CI = 0.83-0.96, P=0.002), systemic lupus erythematosus (SLE) (G vs. A: OR = 0.85, 95% CI = 0.77-0.94, P=0.001), multiple sclerosis (MS) (GG+GA vs. AA: OR = 0.83, 95% CI = 0.70-0.99, P=0.043), systemic sclerosis (SSc) (GG vs. GA: OR = 1.20, 95% CI = 1.07-1.36, P=0.003) and Hashimoto's thyroiditis (HT) (G vs. A: OR = 1.45, 95% CI = 1.10-1.90, P=0.008); the FAS -1377 G/A polymorphism was associated with the risk of autoimmune diseases (A vs. G: OR = 1.11, 95% CI = 1.03-1.20, P=0.008), especially in Asians (A vs. G: OR = 1.15, 95% CI = 1.05-1.25, P=0.002) and high quality studies (A vs. G: OR = 1.14, 95% CI = 1.05-1.24, P=0.002).
CONCLUSION
This meta-analysis demonstrated that the FAS -670A/G and -1377 G/A polymorphisms were associated with the risk of autoimmune diseases.
目的
FAS 在自身免疫性疾病的外在凋亡途径中起着关键作用。之前研究 Fas 基因 -670A/G 和 -1377G/A 多态性与自身免疫性疾病风险之间的关联的结果存在争议。我们进行了荟萃分析来评估这种关联的可能性。
方法
通过检索 PubMed、Embase、CNKI 和万方数据库，我们找到了截至 2018 年 12 月的相关研究。使用比值比（OR）和相应的 95%置信区间（CI）来计算关联。
结果
共有 43 篇文章，包括 67 项研究（52 项 Fas-670A/G 和 15 项 Fas-1377G/A）被纳入荟萃分析。我们的荟萃分析表明，FAS-670A/G 多态性与自身免疫性疾病的风险相关（GG 与 GA：OR=1.079，95%CI=1.004-1.160，P=0.038），尤其是在白种人（GG 与 GA：OR=1.12，95%CI=1.03-1.23，P=0.012）、亚洲人（G 与 A：OR=0.89，95%CI=0.83-0.96，P=0.002）、系统性红斑狼疮（SLE）（G 与 A：OR=0.85，95%CI=0.77-0.94，P=0.001）、多发性硬化症（MS）（GG+GA 与 AA：OR=0.83，95%CI=0.70-0.99，P=0.043）、系统性硬皮病（SSc）（GG 与 GA：OR=1.20，95%CI=1.07-1.36，P=0.003）和桥本甲状腺炎（HT）（G 与 A：OR=1.45，95%CI=1.10-1.90，P=0.008）。FAS-1377G/A 多态性与自身免疫性疾病的风险相关（A 与 G：OR=1.11，95%CI=1.03-1.20，P=0.008），尤其是在亚洲人（A 与 G：OR=1.15，95%CI=1.05-1.25，P=0.002）和高质量研究（A 与 G：OR=1.14，95%CI=1.05-1.24，P=0.002）中。
结论
本荟萃分析表明，FAS-670A/G 和 -1377G/A 多态性与自身免疫性疾病的风险相关。
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