色甘酸二钠对肥大细胞介导的速发型过敏反应的影响。
Effect of disodium cromoglycate on mast cell-mediated immediate-type allergic reactions.
作者信息
Shin Hye-Young, Kim Jung-Sook, An Nyeon-Hyoung, Park Rae-Kil, Kim Hyung-Min
机构信息
College of Pharmacy, VestibuloCochlear Research Center of Wonkwang University, Iksan, Jeonbuk 570-749, South Korea.
出版信息
Life Sci. 2004 Apr 23;74(23):2877-87. doi: 10.1016/j.lfs.2003.10.026.
We investigated the effect of disodium cromoglycate (DSCG) on mast cell-mediated immediate-type hypersensitivity. DSCG inhibited systemic allergic reaction induced by compound 48/80 dose-dependently. Passive cutaneous anaphylaxis was inhibited by 71.6% by oral administration of DSCG (1 g/kg). When DSCG was pretreated at concentration rang from 0.01-1000 g/kg, the serum histamine levels were reduced in a dose dependent manner. DSCG also significantly inhibited histamine release from rat peritoneal mast cell (RPMC) by compound 48/80. We confirmed that DSCG inhibited compound 48/80-induced degranulation of RPMC by alcian blue/nuclear fast red staining. In addition, DSCG showed a significant inhibitory effect on anti-dinitrophenyl IgE-mediated tumor necrosis factor-alpha production. These results indicate that DSCG inhibits mast cell-mediated immediate-type allergic reaction.
我们研究了色甘酸钠（DSCG）对肥大细胞介导的速发型超敏反应的影响。DSCG剂量依赖性地抑制了由化合物48/80诱导的全身过敏反应。口服DSCG（1 g/kg）可使被动皮肤过敏反应受到71.6%的抑制。当DSCG在0.01 - 1000 g/kg的浓度范围内进行预处理时，血清组胺水平呈剂量依赖性降低。DSCG还显著抑制了化合物48/80诱导的大鼠腹膜肥大细胞（RPMC）组胺释放。我们通过阿尔辛蓝/核固红染色证实DSCG抑制了化合物48/80诱导的RPMC脱颗粒。此外，DSCG对抗二硝基苯基IgE介导的肿瘤坏死因子-α产生具有显著抑制作用。这些结果表明DSCG抑制肥大细胞介导的速发型过敏反应。
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