Hanus H, Tůma I
Psychiatrická klinika LF UK Hradec Králové.
Cesk Psychiatr. 1992 Jun;88(2):113-8.
The authors expressed in 1984 the assumption that lithium is the drug of the phenomenon of suicidal action in affective disorders. In the present paper the authors describe in a group of 56 patients with affective disorders in the course of lithioprophylaxis a marked decline of the suicide rate at the 4% level of significance. Therefore the authors are still in favour of the view that lithium is the drug in suicidal behaviour in affective disorders. This mechanism can be explained by the antiaggressive as well as prophylactic action of lithium. In the authors' opinion it is possible that the mechanism of this action may be conditioned by the interference of lithium with the dysfunction of the central serotonergic system.
作者在1984年提出一种假设，即锂是情感障碍中自杀行为现象的药物。在本文中，作者描述了一组56例接受锂盐预防治疗的情感障碍患者，其自杀率在4%的显著性水平上显著下降。因此，作者仍然支持锂是情感障碍自杀行为的药物这一观点。这种机制可以用锂的抗攻击作用和预防作用来解释。作者认为，这种作用机制可能是由于锂干扰了中枢血清素能系统的功能障碍。
