Thies-Flechtner K, Müller-Oerlinghausen B, Seibert W, Walther A, Greil W
Department of Psychiatry, Freie Universität Berlin, Germany.
Pharmacopsychiatry. 1996 May;29(3):103-7. doi: 10.1055/s-2007-979553.
Recent findings have indicated that lithium treatment markedly reduces suicide risk in major affective disorders. To compare the effect of lithium with carbamazepine and amitriptyline, suicidal behavior was analyzed during the randomized prospective long-term MAP study (N = 378; duration 2.5 years). Of the nine suicides and five attempted suicides, none took place during lithium treatment. The findings support the view that lithium has a specific antisuicidal effect over and above its prophylactic benefit.
近期研究结果表明，锂盐治疗可显著降低重度情感障碍患者的自杀风险。为比较锂盐与卡马西平和阿米替林的疗效，在一项随机前瞻性长期心境障碍研究（N = 378；为期2.5年）中对自杀行为进行了分析。在9例自杀和5例自杀未遂事件中，无一发生在锂盐治疗期间。这些发现支持了以下观点：锂盐除了具有预防作用外，还具有特定的抗自杀效应。
