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Structure-activity relationships of untenone A and its derivatives for inhibition of DNA polymerases.

作者信息

Saito Fumiyo, Takeuchi Ryo, Kamino Tomoyuki, Kuramochi Kouji, Sugawara Fumio, Sakaguchi Kengo, Kobayashi Susumu

机构信息

Frontier Research Center for Genome and Drug Discovery, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.

出版信息

Bioorg Med Chem Lett. 2004 Apr 19;14(8):1975-7. doi: 10.1016/j.bmcl.2004.01.092.

DOI:10.1016/j.bmcl.2004.01.092
PMID:15050640
Abstract

We found that untenone A and mannzamenone A inhibit mammalian DNA polymerases alpha and beta, and human terminal deoxynucleotidyl transferase (TdT). The syntheses of both compounds and the structure-activity relationships of untenone A derivatives are described.

摘要

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