白细胞介素-1α（-889）基因多态性与早发性帕金森病之间无关联。

Lack of association between the interleukin-1 alpha (-889) polymorphism and early-onset Parkinson's disease.

作者信息

Möller Jens Carsten, Depboylu Candan, Kölsch Heike, Lohmüller Frank, Bandmann Oliver, Gocke Petra, Du Yansheng, Paus Sebastian, Wüllner Ullrich, Gasser Thomas, Oertel Wolfgang H, Klockgether Thomas, Dodel Richard C

机构信息

Department of Neurology, Philipps-University, Marburg, Germany.

出版信息

Neurosci Lett. 2004 Apr 15;359(3):195-7. doi: 10.1016/j.neulet.2004.01.058.

DOI:10.1016/j.neulet.2004.01.058

PMID:15050696

Abstract

An increasing number of studies have shown that an inflammatory process is part of Parkinson's disease (PD) brain pathology. Interleukin-1 (IL-1) is a multifunctional cytokine and is considered to contribute to several inflammatory diseases. Recently, we detected an associated risk in a subgroup of PD patients with a disease onset < 50 years and a C to T transition in the IL-1alpha promoter (-889). One-hundred-seventy-six German PD patients (42.1 +/- 6.4 years; 42.4% male) and 170 unrelated age-matched control individuals (40.4 +/- 8.7 years; 57.6% male) were investigated for the presence of the IL-1alpha (-889C/T) polymorphism. No significant difference in the allelic distribution of the analyzed IL-1alpha polymorphism has been found between PD and controls. We conclude that the C/T polymorphism in the IL-1alpha promoter region at -889 does not increase the risk to develop PD.

摘要

越来越多的研究表明，炎症过程是帕金森病（PD）脑病理学的一部分。白细胞介素-1（IL-1）是一种多功能细胞因子，被认为与多种炎症性疾病有关。最近，我们在疾病发作年龄<50岁且IL-1α启动子（-889）存在C到T转换的PD患者亚组中检测到一种相关风险。对176名德国PD患者（42.1±6.4岁；42.4%为男性）和170名年龄匹配的无关对照个体（40.4±8.7岁；57.6%为男性）进行了IL-1α（-889C/T）多态性检测。在PD患者和对照之间，所分析的IL-1α多态性的等位基因分布没有发现显著差异。我们得出结论，-889处IL-1α启动子区域的C/T多态性不会增加患PD的风险。