白细胞介素-1α基因多态性对台湾地区晚发型散发性帕金森病有影响。
Interleukin-1 alpha polymorphism has influence on late-onset sporadic Parkinson's disease in Taiwan.
作者信息
Wu Y R, Chen C M, Hwang J C, Chen S T, Feng I H, Hsu H C, Liu C N, Liu Y T, Lai Y Y, Huang H J, Lee-Chen G J
机构信息
Department of Neurology, Chang Gung Memorial Hospital, Chang-Gung University College of Medicine, Taipei, Taiwan.
出版信息
J Neural Transm (Vienna). 2007 Sep;114(9):1173-7. doi: 10.1007/s00702-007-0726-4. Epub 2007 Apr 26.
Inflammatory events may contribute to the pathogenesis of Parkinson's disease (PD) and interleukin 1 (IL-1) may exert both neurotoxic and neuroprotective effects. We conducted a case-control study in a cohort of 493 PD cases and 388 ethnically matched controls to investigate the association of IL-1alpha C-889T and IL-1beta C-511T polymorphisms with the risk of PD. No significant difference in the genotype distribution of the analyzed polymorphisms was found between PD and controls. However, after stratification by age, individuals over 70 years of age carrying IL-1alpha-889 C/T genotype demonstrated a significant decrease in risk of developing PD (OR = 0.44; 95% CI = 0.22-0.88, p = 0.021) and the decrease is strengthened by IL-1beta-511 T-carrying genotype (OR = 0.28; 95% CI = 0.11-0.71, p = 0.008). Our data suggest that IL-1alpha, acting synergistically with IL-1beta, plays role in PD susceptibility among Taiwanese people older than 70 years of age.
炎症事件可能与帕金森病（PD）的发病机制有关，白细胞介素1（IL-1）可能具有神经毒性和神经保护作用。我们在一个由493例PD患者和388例种族匹配的对照组成的队列中进行了一项病例对照研究，以调查IL-1α C-889T和IL-1β C-511T基因多态性与PD风险的关联。在PD患者和对照之间，所分析的多态性的基因型分布没有显著差异。然而，按年龄分层后，携带IL-1α-889 C/T基因型的70岁以上个体患PD的风险显著降低（OR = 0.44；95% CI = 0.22 - 0.88，p = 0.021），并且携带IL-1β-511 T基因型会增强这种降低作用（OR = 0.28；95% CI = 0.11 - 0.71，p = 0.008）。我们的数据表明，IL-1α与IL-1β协同作用，在70岁以上台湾人群的PD易感性中起作用。
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