Mountain R E, Murray J A, Quaba A
Otolaryngology Unit, Royal Infirmary, Edinburgh, UK.
Clin Otolaryngol Allied Sci. 1992 Jun;17(3):223-4. doi: 10.1111/j.1365-2273.1992.tb01831.x.
Associated movements after facial paralysis (synkinesis), due to unphysiological co-innervation of the facial muscles, often complicates the rehabilitation of patients following facial palsy. Clostridium botulinum toxin is a neurotoxin that interferes with the release of acetylcholine from motor nerve end plates, causing skeletal muscular paralysis. This paper concentrates on its clinical use in treating synkinesis affecting orbicularis oculi function and documents the results of treatment in 4 patients. Control of synkinesis, achieved in all 4 patients, was effective within a few days and lasted for 4-6 months. 2 patients developed transient diplopia and ptosis shortly after injection. However, no lasting complications or systemic side-effects were noted. All patients reported a significant improvement in their symptoms and reinjection at 7 months was carried out successfully.
面瘫后的联合运动（联动），由于面部肌肉的非生理性共同支配，常常使面瘫患者的康复变得复杂。肉毒杆菌毒素是一种神经毒素，它会干扰运动神经终板释放乙酰胆碱，导致骨骼肌麻痹。本文重点关注其在治疗影响眼轮匝肌功能的联动方面的临床应用，并记录了4例患者的治疗结果。4例患者均实现了联动控制，数天内即显效，且持续4至6个月。2例患者在注射后不久出现短暂性复视和上睑下垂。然而，未观察到持久的并发症或全身性副作用。所有患者均报告症状有显著改善，且在7个月时成功进行了再次注射。
