Henry Kenneth R
Psychology Department, University of California, Davis, CA 95616-8686, USA.
Hear Res. 2004 Apr;190(1-2):141-8. doi: 10.1016/S0378-5955(03)00401-5.
Gender-related differences in human hearing have been attributed to genetic, environmental, and/or genetic x environmental interactive factors. These differences tend to increase with age, with males showing greater high frequency threshold elevations. An appropriate animal model could aid in prediction, treatment, and prevention of some of these losses. This paper examines inbred strains of mice that are widely used as models of late- (CBA/J and CBA/CaJ) and early- (C57BL/6J) onset age-related hearing loss. In the former two genotypes, the thresholds to high frequency stimuli of the auditory brainstem response (ABR) are higher in the male than in the female. This gender difference was less pronounced in thresholds to the cochlear nerve envelope response of the CBA/CaJ, although this response was more sensitive to the influence of age than was the ABR. In contrast, the male C57BL/6J had more sensitive thresholds than the female, with both measures showing massive loss of sensitivity with increasing age. The data are discussed in terms of the applicability of these animals as tools for examining factors that degrade cochlear function.
人类听力方面与性别相关的差异归因于遗传、环境和/或遗传与环境的交互因素。这些差异往往随着年龄增长而增加，男性的高频阈值升高更为明显。合适的动物模型有助于预测、治疗和预防其中一些听力损失。本文研究了广泛用作迟发性（CBA/J和CBA/CaJ）和早发性（C57BL/6J）年龄相关性听力损失模型的近交系小鼠。在前两种基因型中，听觉脑干反应（ABR）对高频刺激的阈值男性高于女性。尽管CBA/CaJ的耳蜗神经包膜反应阈值对年龄影响的敏感度高于ABR，但这种性别差异在该反应中不太明显。相比之下，雄性C57BL/6J的阈值比雌性更敏感，随着年龄增长，两种测量方法均显示出敏感度大幅下降。本文根据这些动物作为研究损害耳蜗功能因素工具的适用性对数据进行了讨论。
