与血小板激活相关的分支视网膜静脉阻塞。
Branch retinal vein occlusion associated with platelet activation.
出版信息
Turk J Med Sci. 2019 Feb 11;49(1):283-287. doi: 10.3906/sag-1807-223.
Abstract
BACKGROUND/AIM: The aim of this study is to study subclinical platelet activation by detecting three important platelet activation parameters of mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) in patients with branch retinal vein occlusion (BRVO) in comparison to those in healthy control subjects.
MATERIALS AND METHODS
This prospective study included 43 patients with BRVO (Group 1)and 40 control subjects (Group 2). The levels of MPV, PDW, and PCT were measured in both of the studied groups
RESULTS
The mean serum level of MPV value was 7.64 ± 0.64 in Group 1 and 7.39 ± 0.42 in Group 2. Mean serum level of PDW was 15.01 ± 1.56 in Group 1 and 14.43 ± 1.03 in Group 2. Mean serum PCT value was 0.19 ± 0.05 in Group 1 and 0.16 ± 0.04 in Group 2. MPV, PDW, and PCT levels were significantly increased in BRVO patients (P < 0.05).
CONCLUSION
Subclinical platelet activation reflected by MPV, PDW, and PCT may have an impact on the genesis of vessel occlusion in BRVO. The results may be important for the clinical management of patients with BRVO
摘要
背景/目的：本研究旨在通过检测平均血小板体积（MPV）、血小板分布宽度（PDW）和血小板压积（PCT）这三个重要的血小板活化参数，来研究视网膜分支静脉阻塞（BRVO）患者的亚临床血小板活化情况，并与健康对照组进行比较。
材料与方法
这项前瞻性研究纳入了 43 例 BRVO 患者（第 1 组）和 40 例健康对照者（第 2 组）。在两组研究对象中均测量了 MPV、PDW 和 PCT 的水平。
结果
第 1 组的平均血清 MPV 值为 7.64±0.64，第 2 组为 7.39±0.42。第 1 组的平均血清 PDW 值为 15.01±1.56，第 2 组为 14.43±1.03。第 1 组的平均血清 PCT 值为 0.19±0.05，第 2 组为 0.16±0.04。BRVO 患者的 MPV、PDW 和 PCT 水平显著升高（P<0.05）。
结论
MPV、PDW 和 PCT 反映的亚临床血小板活化可能对 BRVO 血管阻塞的发生有影响。这些结果对 BRVO 患者的临床管理可能很重要。
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J Ophthalmol. 2014;2014:724780. doi: 10.1155/2014/724780. Epub 2014 Jun 9.
3
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