Aliyeva Shakhsanam E, Ullmann Andrew J, Kottler Ulrike B, Frising Martine, Schwenn Oliver
Department of Ophthalmology, Johannes Gutenberg-University Hospital, Mainz, Germany.
Graefes Arch Clin Exp Ophthalmol. 2004 Oct;242(10):887-91. doi: 10.1007/s00417-004-0901-3. Epub 2004 Mar 30.
To report the histological findings of an eye with severe Aspergillus endophthalmitis after oral treatment with voriconazole. METHODS. Case report.
Histopathological examination revealed no fungal elements in choroidal or retinal vessels. The hyphae were mainly restricted to the vitreal side of the preretinal inflammatory infiltrate. Since the treatment with voriconazole had not been completed at the time of enucleation, the clinical course with potential further limitation or regression of the lesion remains unsettled.
Endogenous Aspergillus endophthalmitis is a devastating condition often associated with immunodeficiency. The pathogenesis of this entity implies the primary invasion of choroidal and retinal vessels. The lack of antifungal drugs with high blood-ocular permeability results in an extremely poor visual prognosis. Our histological examination indicates promising activity and ocular penetration of the new antifungal agent voriconazole.
报告1例口服伏立康唑治疗后发生严重曲霉菌性眼内炎的眼部组织学检查结果。方法：病例报告。
组织病理学检查显示脉络膜或视网膜血管中无真菌成分。菌丝主要局限于视网膜前炎性浸润的玻璃体一侧。由于眼球摘除时伏立康唑治疗尚未完成，病变是否会进一步局限或消退的临床病程仍不确定。
内源性曲霉菌性眼内炎是一种常与免疫缺陷相关的破坏性疾病。该疾病的发病机制意味着脉络膜和视网膜血管的原发性侵袭。缺乏具有高血眼通透性的抗真菌药物导致视觉预后极差。我们的组织学检查表明新型抗真菌药物伏立康唑具有良好的活性和眼内穿透力。
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