Leung F W, Su K C, Pique J M, Thiefin G, Passaro E, Guth P H
Division of GI, Sepulveda VAMC, California 91343.
Dig Dis Sci. 1992 Sep;37(9):1329-35. doi: 10.1007/BF01296000.
Mucosal hemodynamics (by reflectance spectrophotometry) and mucosal damage (by histologic examination) following acute colonic ischemia were evaluated in different anatomic locations in the colon of anesthetized rats. The reflectance spectrophotometer provides an index of mucosal hemoglobin concentration (IHB) and an index of oxygen saturation of hemoglobin (ISO2). The patterns of ischemia without congestion (decreases IHB, decreases ISO2) during superior mesenteric artery occlusion, and ischemia with congestion (increases IHB, decreases ISO2) during portal vein occlusion, previously demonstrated in the stomach and duodenum, are also applicable to the colon. The significant linear correlations between changes (as percent of baseline) in IHB, ISO2, and hydrogen gas clearance suggest that changes in these indices are adequate indicators of changes in colonic mucosal perfusion. Superior mesenteric artery ligation produced significant reductions in both indices, and an increase in damage in the mucosa of the cecum, transverse colon, splenic flexure, and left colon, but not the rectum. Inferior mesenteric artery ligation produced only slight reduction in these indices and minimal damage only in the mucosa of the splenic flexure. These results support the hypothesis that the superior mesenteric artery is more important than the inferior mesenteric artery in maintaining colonic perfusion and colonic mucosal integrity in the rat.
在麻醉大鼠结肠的不同解剖位置，评估急性结肠缺血后的黏膜血流动力学（通过反射分光光度法）和黏膜损伤（通过组织学检查）。反射分光光度计提供黏膜血红蛋白浓度指数（IHB）和血红蛋白氧饱和度指数（ISO2）。先前在胃和十二指肠中证实的肠系膜上动脉闭塞期间无充血的缺血模式（IHB降低，ISO2降低）以及门静脉闭塞期间充血的缺血模式（IHB升高，ISO2降低），也适用于结肠。IHB、ISO2的变化（以基线百分比表示）与氢气清除率之间存在显著的线性相关性，表明这些指标的变化是结肠黏膜灌注变化的充分指标。肠系膜上动脉结扎导致两个指标均显著降低，且盲肠、横结肠、脾曲和左结肠黏膜损伤增加，但直肠未受影响。肠系膜下动脉结扎仅使这些指标略有降低，且仅在脾曲黏膜造成最小程度的损伤。这些结果支持以下假设：在维持大鼠结肠灌注和结肠黏膜完整性方面，肠系膜上动脉比肠系膜下动脉更重要。
