Elinav Eran, Rabinowitz Yaacov, Lorberbaum Miriam, Nisanewitz Vadim
Department of Medicine, Hadassah University Hospital, Jerusalem, Israel.
Ann Otol Rhinol Laryngol. 2004 Mar;113(3 Pt 1):223-4. doi: 10.1177/000348940411300310.
We describe a patient who had recurrent life-threatening episodes of isolated macroglossia due to the use of an angiotensin-converting enzyme (ACE) inhibitor. No associated facial, labial, pharyngeal, or laryngeal edema was noted. Aggressive treatment with epinephrine, steroids, and antihistamines resulted in rapid resolution of the tongue swelling and respiratory distress. Recurrent isolated angioedema of the tongue is an extremely rare variant of ACE inhibitor-related angioneurotic edema. The widespread use of ACE inhibitors mandates a special awareness by physicians of this potentially life-threatening yet treatable side effect.
我们描述了一名患者，该患者因使用血管紧张素转换酶（ACE）抑制剂而反复出现危及生命的孤立性巨舌症发作。未发现伴有面部、唇部、咽部或喉部水肿。使用肾上腺素、类固醇和抗组胺药进行积极治疗后，舌部肿胀和呼吸窘迫迅速消退。反复出现的孤立性舌血管性水肿是ACE抑制剂相关血管神经性水肿的一种极其罕见的变体。ACE抑制剂的广泛使用要求医生特别注意这种潜在的危及生命但可治疗的副作用。
