Ducote Colten, Kesterke Matthew J, Bhattacharjee Ritesh, Read-Fuller Andrew, Reddy Likith V
Department of Oral and Maxillofacial Surgery, Baylor University Medical Center at DallasDallasTexas.
Department of Oral and Maxillofacial Surgery, Texas A&M University College of DentistryDallasTexas.
Proc (Bayl Univ Med Cent). 2019 Jan 16;32(1):70-72. doi: 10.1080/08998280.2018.1540736. eCollection 2019 Jan.
Presented here are two cases of acute acquired macroglossia in adults caused by angioedema resulting from a reaction to angiotensin-converting enzyme inhibitors (ACEIs). Angioedema can be caused by a variety of factors, but ACEIs are the most common precipitating factor. Symptoms such as swelling of the lips, face, tongue, and throat can lead to life-threatening airway compromise. Early management of acute angioedema and macroglossia includes antihistamines, steroids, and occasionally epinephrine, yet a small percentage of patients progress toward airway obstruction and will require intubation. Edema within the lips, face, and throat usually subsides within a week, but the tongue can remain edematous for prolonged periods if biting trauma occurs. If the patient's macroglossia does not resolve in a reasonable amount of time, a partial glossectomy may be indicated.
本文介绍了两例成人急性获得性巨舌症病例，病因是血管性水肿，由对血管紧张素转换酶抑制剂（ACEIs）的反应引起。血管性水肿可由多种因素导致，但ACEIs是最常见的诱发因素。嘴唇、面部、舌头和喉咙肿胀等症状可导致危及生命的气道阻塞。急性血管性水肿和巨舌症的早期治疗包括使用抗组胺药、类固醇，偶尔使用肾上腺素，但仍有一小部分患者会发展为气道阻塞，需要插管。嘴唇、面部和喉咙的水肿通常在一周内消退，但如果发生咬伤创伤，舌头可能会长期保持水肿状态。如果患者的巨舌症在合理时间内没有消退，可能需要进行部分舌切除术。
