Harizi Hedi, Gualde Norbert
Laboratory of Immunology, Bordeaux University, Bordeaux, France.
Arch Immunol Ther Exp (Warsz). 2004 Jan-Feb;52(1):1-5.
The arachidonic acid (AA)-derived metabolites, termed eicosanoids, are potent lipid mediators with a key role in immune and inflammatory responses. In the immune system, eicosanoids such as prostaglandins (PGs) and leukotrienes (LTs) are produced predominately by antigen-presenting cells (APC), including macrophages and dendritic cells (DC). DC constitute a family of bone marrow-derived professional APC that play a critical role in the induction and modulation of both innate and adaptive immunity. For many years, macrophages were considered as major producers of eicosanoids that are thought to drastically affect their function. Studies concerning the modulation of DC biology by eicosanoids show that PGs and LTs have the potential to affect the maturation, cytokine-producing capacity, Th cell-polarizing ability, and migration of DC. In addition, the development of DC from bone marrow progenitors appears to be under the control of some eicosanoids. Understanding the actions of eicosanoids and their receptors on APC functions is crucial for the generation of efficient DC for therapeutic purposes in patients. In this review, we summarize the current understanding of how DC functions are modulated by eicosanoids.
花生四烯酸（AA）衍生的代谢产物，即类二十烷酸，是一类强效脂质介质，在免疫和炎症反应中起关键作用。在免疫系统中，类二十烷酸如前列腺素（PGs）和白三烯（LTs）主要由抗原呈递细胞（APC）产生，包括巨噬细胞和树突状细胞（DC）。DC是一类源自骨髓的专职APC，在固有免疫和适应性免疫的诱导及调节中起关键作用。多年来，巨噬细胞被认为是类二十烷酸的主要产生者，人们认为这些类二十烷酸会极大地影响其功能。关于类二十烷酸对DC生物学调节的研究表明，PGs和LTs有可能影响DC的成熟、细胞因子产生能力、Th细胞极化能力及迁移。此外，骨髓祖细胞向DC的发育似乎受某些类二十烷酸的调控。了解类二十烷酸及其受体对APC功能的作用对于为患者治疗目的生成高效DC至关重要。在本综述中，我们总结了目前对类二十烷酸如何调节DC功能的理解。
