Shah Ankoor S, Bressler Steven L, Knuth Kevin H, Ding Mingzhou, Mehta Ashesh D, Ulbert Istvan, Schroeder Charles E
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Cereb Cortex. 2004 May;14(5):476-83. doi: 10.1093/cercor/bhh009. Epub 2004 Mar 28.
Event-related potentials (ERPs) provide a critical link between the hemodynamic response, as measured by functional magnetic resonance imaging, and the dynamics of the underlying neuronal activity. Single-trial ERP recordings capture the oscillatory activity that are hypothesized to underlie both communication between brain regions and amplified processing of behaviorally relevant stimuli. However, precise interpretations of ERPs are precluded by uncertainty about their neural mechanisms. One influential theory holds that averaged sensory ERPs are generated by partial phase resetting of ongoing electroencephalographic oscillations, while another states that ERPs result from stimulus-evoked neural responses. We formulated critical predictions of each theory and tested these using direct, intracortical analyses of neural activity in monkeys. Our findings support a predominant role for stimulus-evoked activity in sensory ERP generation, and they outline both logic and methodology necessary for differentiating evoked and phase resetting contributions to cognitive and motor ERPs in future studies.
事件相关电位（ERP）在通过功能磁共振成像测量的血液动力学反应与潜在神经元活动的动力学之间提供了关键联系。单次试验ERP记录捕捉到振荡活动，这些活动被认为是脑区之间通信以及行为相关刺激的放大处理的基础。然而，由于其神经机制的不确定性，对ERP的精确解释受到阻碍。一种有影响力的理论认为，平均感觉ERP是由正在进行的脑电图振荡的部分相位重置产生的，而另一种理论则认为ERP是由刺激诱发的神经反应产生的。我们阐述了每种理论的关键预测，并使用对猴子神经活动的直接皮层内分析对这些预测进行了测试。我们的研究结果支持刺激诱发活动在感觉ERP产生中的主要作用，并且它们概述了未来研究中区分诱发和相位重置对认知和运动ERP贡献所需的逻辑和方法。
