Artico M, Ballati G, Bosco S, Cantarelli D, Nagar G, Grosso A, Leali F M Tranquilli, Cavallotti C
Department of Pharmacology of Natural Molecules and General Physiology, University "La Sapienza," Rome, Italy.
Am J Hematol. 2004 Apr;75(4):241-2. doi: 10.1002/ajh.20005.
The aim of this study was to quantify iron in the placentas at the end of pregnancy in two patients suffering from beta-thalassemia and compare the data to that recorded from the placentas of healthy women. Iron was quantified in placental specimens taken after the delivery. The specimens were subjected to chemical treatments in order to remove extracellular iron and leave the intracellular iron intact. After coloration, each specimen was subjected to quantitative analysis of images in order to identify and quantify iron. Our results demonstrated that in beta-thalassemia there is an accumulation of iron in the outer basal cytoplasm of the epithelial cells of placental cotyledons.
本研究的目的是对两名β地中海贫血患者妊娠末期胎盘内的铁进行定量，并将数据与健康女性胎盘记录的数据进行比较。在分娩后采集的胎盘标本中对铁进行定量。对标本进行化学处理以去除细胞外铁并使细胞内铁保持完整。染色后，对每个标本进行图像定量分析以识别和定量铁。我们的结果表明，在β地中海贫血中，胎盘小叶上皮细胞的外基底细胞质中铁有积累。
