Pavithran Keechilat, Arjun Rajalakshmi, Aruna Raman, Thomas Mathew
Department of Hematology, Medical College Hospital, Trivandrum, India.
Am J Hematol. 2004 Apr;75(4):260-1. doi: 10.1002/ajh.20036.
All-trans-Retinoic acid (ATRA) has been shown to improve survival in patients with acute promyelocytic leukemia (APML). It is a well-tolerated drug except for the serious side effect of ATRA syndrome. Dryness of the skin, cheilitis, and xerostomia are the common mucocutaneous side effects. Occurrence of scrotal ulceration is very rare. We report a 13-year-old boy who had scrotal ulceration caused by ATRA during the induction therapy of APML.
全反式维甲酸（ATRA）已被证明可提高急性早幼粒细胞白血病（APML）患者的生存率。除了ATRA综合征这一严重副作用外，它是一种耐受性良好的药物。皮肤干燥、唇炎和口腔干燥是常见的黏膜皮肤副作用。阴囊溃疡的发生非常罕见。我们报告一名13岁男孩，在APML诱导治疗期间因ATRA导致阴囊溃疡。
