Güllü S, Emral R, Asik M, Cesur M, Tonyukuk V
Department of Endocrinology and Metabolic Diseases, Ankara University, School of Medicine, Ankara, Turkey.
J Endocrinol Invest. 2003 Dec;26(12):1198-202. doi: 10.1007/BF03349157.
Determination of prostatic specific antigen (PSA) in female tissues has become available recently. The expression of PSA gene is under androgenic regulation. Therefore, hyperandrogenemic states, such as polycystic ovary syndrome (PCOS), are expected to be presented with the higher levels of PSA. The current study aimed at evaluating PSA levels in hirsute women presumed to have PCOS or idiopatic hirsutism (IH). Thirty-three patients with PCOS, 40 patients with IH, and 20 healthy control subjects were enrolled in the study. Beside basal hormonal evaluation, total PSA (tPSA), and free PSA (fPSA) were determined in all subjects. Average level of tPSA was the highest in PCOS patients (0.099+/-0.267 ng/ml) when compared with IH and control subjects (p<0.05 and p<0.001, respectively). Besides, mean fPSA levels were found to be significantly higher in patients with PCOS than healthy controls (0.033+/-0.070 vs 0.010+/-0.001 ng/ml; p<0.05). Both total and free PSA levels were found to be higher in 73 hirsute women than in control subjects (p<0.01 and p<0.05, respectively). Women with hyperandrogenemia tended to have higher tPSA than women without hyperandrogenemia (p<0.01). PSA is likely to be used to discriminate hyperandrogenemic hirsutism. If more sensitive assays become available, PSA might be used as a diagnostic criteria for hirsutism and even for some diseases which have hirsutism as a component.
女性组织中前列腺特异性抗原（PSA）的检测方法最近已问世。PSA基因的表达受雄激素调节。因此，预计多囊卵巢综合征（PCOS）等高雄激素血症状态会出现较高水平的PSA。本研究旨在评估疑似患有PCOS或特发性多毛症（IH）的多毛女性的PSA水平。33例PCOS患者、40例IH患者和20名健康对照者纳入本研究。除了基础激素评估外，还测定了所有受试者的总PSA（tPSA）和游离PSA（fPSA）。与IH和对照受试者相比，PCOS患者的tPSA平均水平最高（0.099±0.267 ng/ml）（分别为p<0.05和p<0.001）。此外，发现PCOS患者的平均fPSA水平显著高于健康对照者（0.033±0.070对0.010±0.001 ng/ml；p<0.05）。发现73例多毛女性的总PSA和游离PSA水平均高于对照受试者（分别为p<0.01和p<0.05）。雄激素血症女性的tPSA往往高于无雄激素血症女性（p<0.01）。PSA可能用于鉴别高雄激素血症性多毛症。如果有更敏感的检测方法，PSA可能用作多毛症甚至某些以多毛症为组成部分的疾病的诊断标准。
