Mardanian Farahnaz, Heidari Nasrin
Associate Professor, Department of Obstetric and Gynecology, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2011 Aug;16(8):999-1005.
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women. Its presentation is that of irregular menstruation associated with ovulation defects. Because of adverse outcomes such as metabolic and cardiovascular disorders, its diagnosis and treatment is very important. Therefore, the diagnostic value of prostatespecific antigen (PSA) in women with polycystic ovary syndrome was evaluated.
A total of 32 women with PCOS and 32 aged matched healthy females were recruited in this case-control study. The subjects were compared by means of metabolic measures and serum PSA level. The correlations between these markers were evaluated. Sensitivity and specificity values and cut off levels of PSA were established for diagnosis of PCOS.
Mean PSA, Ferriman Gallwey score (FGS), luteinizing hormone/follicle stimulating hormone ratio (LH/FSH), testosterone, dehydroepiandrosterone sulfate (DHEAS), 17(α) hydroxyprogesterone (17(α) HP) levels were significantly higher in PCOS (P<0.001, respectively). PSA levels greater than 0.07 ng/ml yielded a sensitivity of 91% and specificity of 82%, and was helpful as a diagnostic tool for women with PCOS. Circulating androgens and hirsutism were associated with higher levels of PSA in PCOS women.
Our results showed direct correlation between PSA, hirsutism and hyperandrogemsm state. Therefore, it seems logical to use PSA level for detection of hyperandrogemsm state in women.
多囊卵巢综合征（PCOS）是女性中最常见的内分泌紊乱疾病。其表现为与排卵缺陷相关的月经不规律。由于存在代谢和心血管疾病等不良后果，其诊断和治疗非常重要。因此，评估了前列腺特异性抗原（PSA）在多囊卵巢综合征女性中的诊断价值。
本病例对照研究共纳入32例PCOS女性和32例年龄匹配的健康女性。通过代谢指标和血清PSA水平对受试者进行比较。评估这些指标之间的相关性。确定了PSA用于诊断PCOS的敏感性、特异性值和临界值。
PCOS患者的平均PSA、费里曼-盖尔维评分（FGS）、黄体生成素/卵泡刺激素比值（LH/FSH）、睾酮、硫酸脱氢表雄酮（DHEAS）、17（α）羟孕酮（17（α）HP）水平显著更高（P均<0.001）。PSA水平大于0.07 ng/ml时，敏感性为91%，特异性为82%，有助于作为PCOS女性的诊断工具。循环雄激素和多毛症与PCOS女性较高的PSA水平相关。
我们的结果显示PSA、多毛症和高雄激素血症状态之间存在直接相关性。因此，使用PSA水平检测女性高雄激素血症状态似乎是合理的。
