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肺癌脑转移

Brain metastases in lung cancer.

作者信息

Gaspar Laurie E

机构信息

University of Colorado Health Sciences Center, Department of Radiation Oncology, 1663 N. Ursula Street, Box F-706, Suite 1032, Aurora, CO 80010-0510, USA.

出版信息

Expert Rev Anticancer Ther. 2004 Apr;4(2):259-70. doi: 10.1586/14737140.4.2.259.

DOI:10.1586/14737140.4.2.259
PMID:15056056
Abstract

Brain metastases secondary to primary non-small cell and small cell lung cancer have become an important area of research. The brain is one of the most common sites of failure following treatment for locally advanced non-small cell lung cancer, often as the only site. Treatment strategies and the outcome for brain metastases from lung cancer may differ from brain metastases arising from other primary cancers. This article reviews the prognostic factors associated with brain metastases from lung cancer, as well as current treatment approaches with chemotherapy, surgery and radiation therapy.

摘要

继发于原发性非小细胞肺癌和小细胞肺癌的脑转移瘤已成为一个重要的研究领域。脑是局部晚期非小细胞肺癌治疗后最常见的失败部位之一,通常是唯一的部位。肺癌脑转移瘤的治疗策略和结果可能与其他原发性癌症引起的脑转移瘤不同。本文综述了与肺癌脑转移瘤相关的预后因素,以及目前化疗、手术和放射治疗的治疗方法。

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Brain metastases in lung cancer.肺癌脑转移
Expert Rev Anticancer Ther. 2004 Apr;4(2):259-70. doi: 10.1586/14737140.4.2.259.
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Does the incidence and outcome of brain metastases in locally advanced non-small cell lung cancer justify prophylactic cranial irradiation or early detection?局部晚期非小细胞肺癌脑转移的发生率和转归是否支持预防性颅脑照射或早期检测?
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High risk of brain metastases in surgically staged IIIA non-small-cell lung cancer patients treated with surgery, chemotherapy, and radiation.接受手术、化疗和放疗的手术分期为IIIA期的非小细胞肺癌患者发生脑转移的风险较高。
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Chemotherapy is the cornerstone of the combined surgical treatment of lung cancer with synchronous brain metastases.化疗是肺癌合并同步脑转移联合手术治疗的基石。
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[Factors affecting the prognosis in patients with primary lung cancer and brain metastases].[影响原发性肺癌合并脑转移患者预后的因素]
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Association of neurologic manifestations and CEA levels with the diagnosis of brain metastases in lung cancer patients.神经系统表现和 CEA 水平与肺癌脑转移患者诊断的相关性。
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Surgical intervention may be a therapeutic option for NSCLC patients with AJCC stage IV: a large population-based study.手术干预可能是美国癌症联合委员会(AJCC)IV期非小细胞肺癌(NSCLC)患者的一种治疗选择:一项基于大规模人群的研究。
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