Casellas Francesc, Alcalá Maria-José, Prieto Luis, Miró José-Ramón Armengol, Malagelada Juan-Ramón
Digestive System Research Unit, Hospital Universitari Vall d' Hebron, Spanish Group for the Study of Methodology in Clinical Research, Barcelona, Spain.
Am J Gastroenterol. 2004 Mar;99(3):457-61. doi: 10.1111/j.1572-0241.2004.04071.x.
Inflammatory bowel disease impairs health-related quality of life. Therefore, it is very important to develop adequate instruments to measure the disease impact, but these instruments need to be practical as well as accurate. Our aim was to determine whether a short questionnaire obtained from the reduction of the 36-item version of the inflammatory bowel disease questionnaire (IBDQ-36) accurately reflects the impact of clinical and endoscopic activity on health-related quality of life.
To this purpose the original IBDQ-36 and a reduced version, composed of only 9 items (IBDQ-9), were administered to 68 patients with inflammatory bowel disease. Disease activity was established by standard clinical activity indices (Rachmilewitz for ulcerative colitis (UC) and Harvey-Bradshaw for Crohn's disease (CD)) and by information gathered at colonoscopy.
In UC patients the Spearman's correlation coefficients between IBDQ-9 and clinical and colonoscopic indices were statistically significant (-0.67 and -0.70, respectively, p < 0.01) and similar to those obtained with IBDQ-36 (-0.61 and -0.67). In CD patients IBDQ-9 also correlated well with the clinical index (-0.59, p < 0.05) but less with the colonoscopic index (-0.30, p= 0.1). In CD patients, the correlation of the IBDQ-36 with clinical and colonoscopic indices gave similar results to the IBDQ-9 (-0.58 and -0.21, respectively). The IBDQ-9 power to discriminate between clinical relapse and remission was statistically significant (p < 0.01) both for UC (55 (48-57) vs 69 (63-75) and CD (58 (51-63) vs 69 (64-83)) patients. Similar results were obtained for conoloscopic indices of endoscopic relapse and remission (56 (52-65) vs 70 (66-77) in UC and 58 (52-63) vs 68 (62-73) in CD).
Quality of life impairment produced by relapses of inflammatory bowel disease can be reliably assessed with a short questionnaire, with considerable savings in time and expense.
炎症性肠病会损害健康相关生活质量。因此，开发合适的工具来衡量疾病影响非常重要，但这些工具需要既实用又准确。我们的目的是确定从36项炎症性肠病问卷（IBDQ - 36）简化而来的简短问卷是否能准确反映临床和内镜活动对健康相关生活质量的影响。
为此，将原始的IBDQ - 36和仅由9个项目组成的简化版本（IBDQ - 9）应用于68例炎症性肠病患者。通过标准临床活动指数（溃疡性结肠炎（UC）采用 Rachmilewitz 指数，克罗恩病（CD）采用 Harvey - Bradshaw 指数）以及结肠镜检查收集的信息来确定疾病活动度。
在UC患者中，IBDQ - 9与临床和结肠镜检查指数之间的斯皮尔曼相关系数具有统计学意义（分别为 - 0.67和 - 0.70，p < 0.01），且与IBDQ - 36获得的结果相似（分别为 - 0.61和 - 0.67）。在CD患者中，IBDQ - 9与临床指数也有良好的相关性（ - 0.59，p < 0.05），但与结肠镜检查指数的相关性较弱（ - 0.30，p = 0.
