Barle Hans, Hållström Lars, Essèn Pia, Thörne Anders, McNurlan Margaret A, Garlick Peter J, Wernerman Jan
Department of Anesthesiology/Intensive Care, Danderyd Hospital, Stockholm, Sweden.
Clin Physiol Funct Imaging. 2004 Mar;24(2):91-5. doi: 10.1111/j.1475-097X.2004.00535.x.
In previous studies, a decline in total liver protein synthesis during elective laparoscopic surgery has been observed. However, when albumin synthesis was measured in parallel no apparent influence of the procedure was detected. The aim of the present study was to specifically investigate the effect of a laparoscopic procedure on albumin synthesis. Female (n = 9) patients scheduled for elective laparoscopic cholecystectomy as a consequence of cholecystolithiasis were investigated. The fractional synthesis rate (FSR) of albumin was investigated twice in each patient, before and during surgery (2-3 h apart), employing L-[2H5]phenylalanine and gas chromatography mass spectrometry. The FSR of albumin decreased from 7.3 +/- 1.2% per day before surgery to 6.2 +/- 1.4% per day during the procedure (P<0.01), whereas the corresponding absolute synthesis rates of albumin decreased from 114 +/- 24 to 86 +/- 16 mg kg(-1) day(-1), respectively (P<0.001). In conclusion, the synthesis rate of albumin decreased during a laparoscopic surgery procedure. However, the characteristics for this decrease differ from those previously observed for total liver protein synthesis.
在先前的研究中，已观察到择期腹腔镜手术期间肝脏总蛋白合成下降。然而，同时测量白蛋白合成时，未检测到该手术有明显影响。本研究的目的是专门调查腹腔镜手术对白蛋白合成的影响。对因胆囊结石而计划进行择期腹腔镜胆囊切除术的女性患者（n = 9）进行了研究。采用L-[2H5]苯丙氨酸和气相色谱质谱法，在每位患者手术前和手术期间（间隔2 - 3小时）各两次调查白蛋白的分数合成率（FSR）。白蛋白的FSR从手术前每天7.3±1.2%降至手术期间每天6.2±1.4%（P<0.01），而相应的白蛋白绝对合成率分别从114±24降至86±16 mg kg(-1) 天(-1)（P<0.001）。总之，腹腔镜手术期间白蛋白合成率下降。然而，这种下降的特征与先前观察到的肝脏总蛋白合成的特征不同。
